Arjen Robben was injured as Bayern Munich reached the German Cup quarter-finals while Inter Milan, Chievo Verona and Atalanta made the Coppa Italia last 16.
Bayern Munich are on path for another treble after beating Augsburg 2-0, while Bayer Leverkusen, VfL Wolfsburg and Eintracht Frankfurt all booked their places in the quarter-finals.
But it was a costly win for Pep Guardiola’s side as Arjen Robben leave the pitch on a stretcher after been sent tumbling by Augsburg goalkeeper Marwin Hitz. Robben as reportedly suffered a “deep cut” on his right knee and the full extent of the injury will only be known after a scan on Thursday.
Robben has been in outstanding form for Bayern recently, scoring in each of his last four matches for the Bundesliga leaders.
Emre Can struck with 13 minutes left to give Leverkusen a 2-1 win at Bundesliga rivals Freiburg while a last-gasp Ivica Olić goal completed a comeback victory by the same score for Wolfsburg against second-division Ingolstadt 04, whose fellow second-tier side SV Sandhausencame back from two behind to level only to lose 4-2 in Frankfurt.
Bayern, Leverkusen, Wolfsburg and Eintracht join Tuesday winners Hamburg, Borussia Dortmund, Hoffenheim and sole second division survivors Kaiserslautern in the quarter-finals, which will be played on 11 and 12 February.
Inter Milan, Chievo Verona and Atalanta all reached the last 16 of the Coppa Italia on Wednesday. In the only all-Serie A encounter, Atalanta beat Sassuolo 2-0 to avenge last month’s league defeat by the same score. Chievo Verona beat Serie B team Reggina 4-1 and Inter Milan hung on to beat Serie B team Trapani 3-2.
The last fourth-round tie is played when Sampdoria host Serie A rivals Verona on Thursday, with Parma and second-tier trio Spezia, velino and Siena having all advanced on Tuesday.
Round of 16 draw
AC Milan v Spezia
Udinese v Inter Milan
Fiorentina v Chievo Verona
Catania v Siena
AS Roma v Sampdoria/Hellas Verona
Juventus v Avelino
Lazio (holders) v Parma
Napoli v Atalanta