Antonio Conte’s free-scoring Inter side got the opener at the RheinEnergieStadion, with Romelu Lukaku netting his 34th goal of the season from the penalty spot with only five minutes on the clock.
Following United’s prolonged run in the Europa League, Ole Gunnar Solskjaer’s side will sit out the opening round of the new campaign.
With their trip to Burnley postponed, United will instead start the season against Crystal Palace at Old Trafford on the weekend of September 19.
After then visiting Brighton, United face a tricky set of games.
City will instead feature just twice in the Premier League in September – the trip to Wolves followed by their first home match of the season against Leicester.
An away date at Leeds will take place at the start of October before the international break, meaning that City will have only played three times in the league before the clash with Arsenal on October 17.
The first north London derby will take place at the Tottenham Hotspur Stadium on December 5, while the reverse fixture at the Emirates is scheduled for March 13.
The new White Hart Lane is the best stadium in Europe and we have tickets to all of the Spurs home games.
Jurgen Klopp’s side, who won the 2019/20 title by 18 points, welcome Leeds back to the Premier League after their 16-year absence on the weekend of September 12, before going to Chelsea on the weekend of September 19.
That’s followed by the first Merseyside derby of the campaign on October 17 at Goodison Park, following the international break. The return Merseyside derby at Anfield is scheduled for February 20.
Liverpool go to last season’s nearest challengers Manchester City on November 7, and then host City at Anfield on February 6.
The Blues will finish off their campaign with a daunting run-in: games against Manchester City, Arsenal and Leicester are followed by a trip to Villa Park on the final day of the season on May 23.
Mikel Arteta’s side will also have their eyes set on December 5 and March 13, the two dates for the North London derby against Tottenham; with the latter being held at the Emirates.
Arsenal also have been set up with a blockbuster Boxing Day clash against London rivals Chelsea. They open their season against newly-promoted Fulham on September 12.
Carlo Ancelotti’s side will be looking to improve on finishing 12th last term, and they will hope to get off to a fast start with West Brom the visitors in their first home game on September 19 followed by a trip to Selhurst Park to face Crystal Palace on September 26.
The Eagles host rivals Brighton in their fifth game on October 17 and head to the Amex on February 13.
Crystal Palace Premier League Fixtures
12: Southampton (h)
19: Manchester United (a)
26: Everton (h)
3: Chelsea (a)
17: Brighton (h)
24: Fulham (a)
31: Wolves (a)
October’s schedule looks particularly challenging as West Ham travel to Leicester, Tottenham and Liverpool with their only home fixture that month coming against Manchester City – who beat them 5-0 at the London Stadium on the opening weekend of last season
The trip to Chelsea comes on December 19 with the reverse fixture at home on April 24. Tottenham make their visit on February 20.