The quartet are already assured of a playoff spot and will be drawn the first position in Groups A–D to ensure they each have two dates free to play the Nations League Finals in June.
The former also applies to the group winners in Leagues B, C and D, namely Bosnia-Herzegovina, Ukraine, Denmark, Sweden, Scotland, Norway, Serbia, Finland, Georgia, FYR Macedonia, Kosovo and Belarus.
Italy and the five other nations in Pot 1 will be drawn into the first position in Groups E-J, meaning they cannot face a Nations League finalist.
However, the Azzurri could still be paired with old enemy Germany or Sweden, who eliminated them from the 2018 World Cup playoffs.
Euro 2020 qualifying pots in full:
Nations League pot: Switzerland, Portugal, Netherlands, England
Pot 1: Belgium, France, Spain, Italy, Croatia, Poland
Pot 2: Germany, Iceland, Bosnia and Herzegovina, Ukraine, Denmark, Sweden, Russia, Austria, Wales, Czech Republic
Pot 3: Slovakia, Turkey, Republic of Ireland, Northern Ireland, Scotland, Norway, Serbia, Finland, Bulgaria, Israel
Pot 4: Hungary, Romania, Greece, Albania, Montenegro, Cyprus, Estonia, Slovenia, Lithuania, Georgia
Pot 5: FYR Macedonia, Kosovo, Belarus, Luxembourg, Armenia, Azerbaijan, Kazakhstan, Moldova, Gibraltar, Faroe Islands
Pot 6: Latvia, Liechtenstein, Andorra, Malta, San Marino