Between them, the four semi-finalists have won the FA Cup 32 times, with Arsenal leading the way with 12.
Chelsea and Spurs met at the same stage in 2012 when the Blues ran out 5-1 winners through goals from Didier Drogba, Juan Mata, Ramires, Frank Lampard and Florent Malouda.
“Tottenham have given Chelsea problems this season and it is a London derby too so gives it an edge,” said former Chelsea midfielder Frank Lampard, speaking as a BBC Match of the Day pundit after the Blues’ quarter-final win.
“They are two very form teams but I think Chelsea are slight favourites as it stands.”
Amazingly Arsenal and City have met just twice before at any stage in the competition, the most recent of which was a 2-1 fifth-round win for the Gunners in 1971.
The ties will be played on Saturday, April 22 and Sunday, April 23 with the final to take place at Wembley on Saturday, May 27. Kick-off times will be decided closer to the time as will TV coverage.