Manchester United were drawn against AC Milan in the most high-profile tie in Europa League round-of-16 draw.
The draw saw Arsenal face the side who eliminated them from the competition last season in Olympiakos, while AS Roma and Shakhtar Donetsk, Champions League regulars in recent seasons, will play one another.
Between them, United and Milan have won a total of 10 European Cup/Champions League titles. They last faced each other in the Champions League round of 16 in 2010, when United won 7-2 on aggregate.