The game against the Galaxy on July 24 will hold a particular significance for the club as former Spurs skipper Robbie Keane and ex-England captain David Beckham play for the MLS side.
Spurs will also line up against former Arsenal striker Thierry Henry when they take on the Red Bulls in the inaugural New York Invitational Cup on July 31.
Tottenham manager Harry Redknapp, a former Seattle Sounders player who took Spurs to the US for their pre-season tour two years ago, said: “Playing the winners of the MLS Cup in LA Galaxy will provide a real challenge.
“Any team that includes proven international performers like Robbie Keane, Landon Donovan and David Beckham are sure to be top drawer.
“I have fantastic memories of America from my days playing at Seattle Sounders and, more recently, our last visit there two years ago.
“The facilities will be first class and the opposition will provide a great test for the squad.”
Spurs USA Tour Tickets
July 24: LA Galaxy v Totteham Hotspur – Buy LA Galaxy v Spurs Tickets
July 28: Liverpool v Spurs in Baltimore – Buy Liverpool v Spurs Tickets
July 31: New York Red Bulls v Tottenham Hotspur – Buy NY Red Bulls v Spurs Tickets